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Staley, Jonathan P.

One or more keywords matched the following properties of Staley, Jonathan P.

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overview	Our goal is to understand the mechanism and regulation of nuclear pre-mRNA splicing, an essential step in eukaryotic gene expression. Pre-mRNA splicing is catalyzed by a massive multimegadalton ribonucleoprotein machine called the spliceosome. Using the model organism S. cerevisiae as well as human cells, we apply a wide array of approaches, ranging from single molecule microscopy, biophysics, and chemical biology to biochemistry and cell biology to genetics and genomics to gain a deep understanding of how the spliceosome catalyzes and regulates pre-mRNA splicing, including in the context of transcription.

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overview

Our goal is to understand the mechanism and regulation of nuclear pre-mRNA splicing, an essential step in eukaryotic gene expression. Pre-mRNA splicing is catalyzed by a massive multimegadalton ribonucleoprotein machine called the spliceosome. Using the model organism S. cerevisiae as well as human cells, we apply a wide array of approaches, ranging from single molecule microscopy, biophysics, and chemical biology to biochemistry and cell biology to genetics and genomics to gain a deep understanding of how the spliceosome catalyzes and regulates pre-mRNA splicing, including in the context of transcription.

One or more keywords matched the following items that are connected to Staley, Jonathan P.

Item Type	Name
Concept	Cell Nucleus
Concept	HeLa Cells
Concept	Cell Line, Tumor
Concept	DNA, Single-Stranded
Academic Article	Mechanical devices of the spliceosome: motors, clocks, springs, and things.
Academic Article	An RNA switch at the 5' splice site requires ATP and the DEAD box protein Prp28p.
Academic Article	Specific alterations of U1-C protein or U1 small nuclear RNA can eliminate the requirement of Prp28p, an essential DEAD box splicing factor.
Academic Article	The splicing factor Prp43p, a DEAH box ATPase, functions in ribosome biogenesis.
Academic Article	DEAD on.
Academic Article	Assembly of ribosomes and spliceosomes: complex ribonucleoprotein machines.
Academic Article	The EF-G-like GTPase Snu114p regulates spliceosome dynamics mediated by Brr2p, a DExD/H box ATPase.
Academic Article	Evidence that U2/U6 helix I promotes both catalytic steps of pre-mRNA splicing and rearranges in between these steps.
Academic Article	Autosomal-dominant retinitis pigmentosa caused by a mutation in SNRNP200, a gene required for unwinding of U4/U6 snRNAs.
Academic Article	The DEAH box ATPases Prp16 and Prp43 cooperate to proofread 5' splice site cleavage during pre-mRNA splicing.
Academic Article	Complete folding of bovine pancreatic trypsin inhibitor with only a single disulfide bond.
Academic Article	RNA catalyses nuclear pre-mRNA splicing.
Academic Article	Spliceosomal DEAH-Box ATPases Remodel Pre-mRNA to Activate Alternative Splice Sites.
Academic Article	Cancer therapies activate RIG-I-like receptor pathway through endogenous non-coding RNAs.
Academic Article	Specific Recognition of a Single-Stranded RNA Sequence by a Synthetic Antibody Fragment.
Academic Article	The Evolutionarily-conserved Polyadenosine RNA Binding Protein, Nab2, Cooperates with Splicing Machinery to Regulate the Fate of pre-mRNA.
Academic Article	Profiling lariat intermediates reveals genetic determinants of early and late co-transcriptional splicing.

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